Chronic Leukemia

In this lecture, Professor Zach Murphy delivers a comprehensive and high-yield breakdown of Chronic Leukemia, diving deep into the pathophysiology, clinical presentation, and diagnostic features of both Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL). This video provides a clear, structured approach to understanding these hematologic malignancies, equipping you with the tools needed for both clinical application and board exam mastery.

We begin by reviewing the underlying pathogenesis of CML and CLL, including the role of the BCR-ABL fusion gene and Philadelphia chromosome in CML, as well as the immunophenotypic markers and lymphocytic dysfunction seen in CLL. Zach then transitions into a detailed discussion of hallmark laboratory findings, peripheral blood smear features, and diagnostic tests such as flow cytometry and FISH analysis.

The lecture continues with an in-depth review of the clinical manifestations and complications of chronic leukemia, including symptoms of anemia, splenomegaly, infections, and Richter transformation. You’ll also learn how to distinguish these disorders from other leukemias and lymphoproliferative conditions based on history, labs, and disease progression.

This lecture concludes with a high-yield overview of treatment strategies, including tyrosine kinase inhibitors like imatinib for CML and targeted agents like BTK inhibitors and venetoclax for CLL. With integrated tables, clinical pearls, and board-style insights, this session is perfect for students preparing for exams such as the USMLE, COMLEX, and PANCE. Enjoy the lecture and please support us below!

Table of Contents

0:00 Intro
0:42 Pathophysiology of Chronic Leukemia
21:12 Causes of Chronic Leukemia
30:47 Complications of CML
48:27 Complications of CLL
1:08:44 Diagnostic Approach to Chronic Leukemia
1:17:42 Treatment of Chronic Leukemia
1:24:01 Comment, Like, SUBSCRIBE!