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Venous Thromboembolism

Pathology
Podcast
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Ninja Nerds!

Professor Zach Murphy will present on Venous Thromboembolism, including Pulmonary Embolism (PE) and Deep Vein Thrombosis (DVT). We will be going into detail on the following main objectives:

1. Definition and Classification of Venous Thromboembolism

- Acquire an in-depth understanding of Venous Thromboembolism, a condition involving the formation of blood clots in the venous system.

- Explore the two main types of VTE: Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE).

2. Pathophysiology and Etiologies

- Uncover the underlying mechanisms leading to VTE, focusing on the triad of stasis, hypercoagulability, and endothelial injury.

- Investigate common risk factors such as surgery, malignancy, immobility, and inherited clotting disorders.

3. Clinical Manifestations and Presentation

- Identify key signs and symptoms for DVT, including leg swelling, pain, and erythema, and for PE, such as dyspnea, chest pain, and hemoptysis.

- Recognize how to differentiate between DVT and PE based on clinical presentation and risk factors.

4. Diagnostic Criteria and Tools

- Familiarize yourself with the diagnostic modalities available, such as ultrasound for DVT and CT pulmonary angiography for PE.

- Learn about risk stratification tools like the Wells Criteria and the Pulmonary Embolism Rule-out Criteria (PERC).

5. Initial Management Strategies

- Understand evidence-based approaches for immediate management, including anticoagulation therapy and supportive care.

- Explore the indications for pharmacologic thrombolysis and mechanical thrombectomy.

6. Definitive Management Approaches

- Examine long-term treatment options, such as vitamin K antagonists and direct oral anticoagulants (DOACs).

- Evaluate the criteria for treatment duration and the role of inferior vena cava (IVC) filters.

7. Complications and Prognosis

- Discuss potential complications like post-thrombotic syndrome, chronic thromboembolic pulmonary hypertension, and recurrent VTE events.

- Consider prognostic factors, including the presence of comorbid conditions, the extent of clot burden, and response to initial treatment.

Table of Contents:

0:00 Lab

0:07 Venous Thromboembolism Introduction

0:14 Pathophysiology of DVT

5:01 Issues with DVT

6:03 Diagnostic Approach to DVT

9:09 Treatment of DVT

10:34 Pathophysiology of Pulmonary Embolism

11:59 Issues with Pulmonary Embolism

14:23 Diagnostic Approach to Pulmonary Embolism

20:39 Treatment of Pulmonary Embolism

23:24 Comment, Like, SUBSCRIBE!

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