Myeloproliferative Neoplasias (MPN)

In this lecture, Professor Zach Murphy delivers a comprehensive and high-yield breakdown of Myeloproliferative Neoplasias (MPNs), focusing on the pathophysiology, clinical features, and diagnostic evaluation of these hematologic disorders. This lecture gives you a clear and organized approach to understanding the major subtypes of MPNs and how they present in clinical practice.

We begin with an overview of normal myeloid hematopoiesis, followed by a deep dive into the molecular pathogenesis of MPNs, including the key driver mutations such as JAK2 V617F, CALR, and MPL. We then cover the four major classic MPNs—Polycythemia Vera, Essential Thrombocythemia, Primary Myelofibrosis, and Chronic Myeloid Leukemia (CML)—emphasizing their unique clinical findings, lab patterns, and mutation profiles.

This lecture explores hallmark features of each condition: erythrocytosis and aquagenic pruritus in PV, thrombocytosis and vasomotor symptoms in ET, bone marrow fibrosis and splenomegaly in PMF, and the BCR-ABL fusion gene and leukocytosis in CML. We also review potential complications, including thrombosis, hemorrhage, leukemic transformation, and marrow failure.

We use visual aids, flowcharts, and comparative tables to explain the diagnostic criteria, peripheral smear findings, and key differences between each MPN. You’ll also learn the treatment strategies, from phlebotomy and hydroxyurea to JAK inhibitors like ruxolitinib and tyrosine kinase inhibitors such as imatinib for CML.

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Table of Contents:

0:00 Lab
1:00 Pathophysiology of Myeloproliferative Neoplasia
36:37 Complications | Thrombosis
48:06 Complications | Bleeding
54:25 Complications | Splenomegaly
1:06:28 Diagnostic Approach to Myeloproliferative Neoplasia
1:15:58 Treatment of Myeloproliferative Neoplasia
1:23:22 Comment, Like, SUBSCRIBE!

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