Lung Cancer

In this lecture, Professor Zach Murphy discusses lung cancer, one of the leading causes of cancer-related deaths worldwide. This session breaks down the essential features of both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), focusing on pathophysiology, histologic subtypes, clinical presentation, diagnostic strategies, and treatment options.

We begin by exploring risk factors, including tobacco exposure, environmental carcinogens, and genetic predispositions. Zach then walks through the histologic classifications, covering adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and small cell carcinoma, emphasizing their distinct characteristics, locations within the lung, and typical clinical manifestations.

The lecture highlights paraneoplastic syndromes—such as SIADH, Cushing syndrome, and Lambert-Eaton myasthenic syndrome—and how they commonly present with SCLC. We also discuss the importance of imaging modalities like chest X-ray, CT, and PET scans, along with biopsy techniques and molecular testing for driver mutations (e.g., EGFR, ALK, ROS1) that guide targeted therapies.

Finally, we review staging (TNM system for NSCLC and limited/extensive staging for SCLC) and corresponding treatment approaches, including surgery, chemotherapy, radiation, immunotherapy, and targeted agents, depending on the tumor type and disease progression.Enjoy the lecture and support us below!

Table of Contents:
0:00 Lab
0:45 Pathophysiology and Causes of Lung Cancer
42:17 Compressive Effects of Lung Tumors
1:02:32 Paraneoplastic Syndromes
1:30:10 Metastasis
1:39:02 Diagnostic Approach to Lung Cancer
2:10:18 Treatment of Lung Cancer
2:23:40 Comment, Like, SUBSCRIBE!

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