Esophageal and Gastric Cancer

Ninja Nerds!

In this lecture, Professor Zach Murphy delivers a comprehensive breakdown of Esophageal and Gastric Cancer, combining a detailed whiteboard discussion with our integrated digital presentation to give you the foundational understanding and the applied clinical framework you need.

We begin with esophageal cancer, reviewing the differences between adenocarcinoma and squamous cell carcinoma. Zach explains the key risk factors, such as GERD, Barrett esophagus, smoking, and alcohol use, while highlighting the hallmark symptoms, including progressive dysphagia and weight loss.

The session then transitions into our digital presentation, where we walk through the diagnostic evaluation and treatment strategies step by step. You will see how to approach esophageal cancer using tools like barium swallow, EGD with biopsy, endoscopic ultrasound, and CT imaging for staging. Then, management pathways range from endoscopic resection in early disease to neoadjuvant chemoradiation and esophagectomy in advanced cases.

Next, we explore gastric cancer, focusing on intestinal-type adenocarcinoma often associated with chronic H. pylori infection and long-standing gastritis. Zach reviews the classic clinical features such as early satiety, melena, and epigastric discomfort. Our digital presentation then guides you through the staging process with EGD, biopsy, and imaging, along with treatment decisions including gastrectomy with lymph node dissection and the role of perioperative chemotherapy.

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Table of Contents:
0:00 Lab
0:51 Pathophysiology of Esophageal and Gastric Cancer
25:52 Classic Findings and Complications of Esophageal Cancer
36:31 Classic Findings and Complications of Gastric Cancer
52:41 Diagnostic Approach to Esophageal Cancer
1:01:10 Diagnostic Approach to Gastric Cancer
1:06:57 Treatment Approach to Esophageal Cancer
1:10:25 Treatment Approach to Gastric Cancer
1:13:38 Comment, Like, SUBSCRIBE!