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In this lecture, Professor Zach Murphy delivers a comprehensive and high-yield breakdown of Lymphoma, focusing on the pathophysiology, classification, and clinical presentation of both Hodgkin and Non-Hodgkin lymphoma. This detailed session provides a clear, structured approach to understanding the malignant transformation of lymphoid cells and how these diseases present across various clinical settings.
We begin with an overview of the normal lymphatic system, then transition into the mechanisms of lymphomagenesis, including the role of genetic mutations, viral associations (such as EBV), and immune dysregulation. We then cover the Reed-Sternberg cells and their diagnostic significance in Hodgkin lymphoma, followed by a deep dive into the subtypes of both Hodgkin and Non-Hodgkin lymphoma, including their characteristic features, epidemiology, and typical presentations.
This lecture further explores clinical manifestations—such as painless lymphadenopathy, B symptoms, and extranodal involvement—and provides an organized review of the diagnostic workup, including excisional biopsy, immunophenotyping, and staging with PET-CT. We also walk through high-yield differences in prognosis and treatment strategies, from chemotherapy regimens like ABVD to targeted therapies like rituximab, and the indications for radiation and stem cell transplantation.
We conclude with a high-yield summary of the most tested facts on lymphoma for exams like the USMLE, COMLEX, and PANCE, including visual aids, clinical pearls, and memory hooks to solidify your understanding. Whether you’re prepping for boards or reviewing hematology-oncology, this lecture is your ultimate guide to mastering lymphoma. Enjoy the lecture and support us below!
Table of Contents:
0:00 Lab
0:32 Pathophysiology of Hodgkin Lymphoma
26:10 Pathophysiology of Non-Hodgkin Lymphoma
58:54 Complications | Lymphadenopathy
1:03:39 Complications | Mediastinal Mass
1:10:43 Complications | B-symptoms
1:14:21 Complications | Extranodal Disease
1:28:08 Complications | Tumor Lysis Syndrome
1:33:25 Diagnostic Approach to Lymphoma
1:47:11 Treatment of Lymphoma
1:56:18 Comment, Like, SUBSCRIBE!