Prostate Cancer

Ninja Nerds!

In this lecture, Professor Zach Murphy presents a high-yield discussion on prostate cancer, the most commonly diagnosed non-skin cancer in men and a significant cause of cancer-related mortality. This session walks you through the key features of the disease, from pathogenesis to diagnosis and management.

We begin by examining epidemiology and risk factors, including age, African American ancestry, family history, and hormonal influences such as androgen receptor signaling. Zach then outlines the pathophysiology behind prostate cancer development and progression, highlighting how dysregulated cell growth leads to prostatic tissue transformation.

The lecture details clinical presentation, which can range from asymptomatic cases found through screening to urinary symptoms, bone pain due to metastases, or signs of spinal cord compression. We also cover the roles and limitations of PSA screening, digital rectal exam, and the use of transrectal ultrasound-guided prostate biopsy, including the significance of the Gleason score for grading tumor aggressiveness.

Finally, we discuss imaging modalities like multiparametric MRI and bone scans and treatment strategies based on risk stratification, such as active surveillance, radical prostatectomy, radiation therapy, and androgen deprivation therapy (ADT). Emerging therapies and precision medicine approaches are also discussed to provide a complete understanding.

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Table of Contents:

0:00 Lab
0:37 Pathophysiology of Prostate Cancer
16:59 Complications of Prostate Cancer
27:57 Metastasis
37:52 Diagnostic Approach to Prostate Cancer
52:27 Treatment of Prostate Cancer
1:03:10 Comment, Like, SUBSCRIBE!

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